Kevin D Read Selected Research

Nifurtimox

1/2017	Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi.
10/2016	Nitroheterocyclic drugs cure experimental Trypanosoma cruzi infections more effectively in the chronic stage than in the acute stage.
9/2015	Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease.
10/2013	The R enantiomer of the antitubercular drug PA-824 as a potential oral treatment for visceral Leishmaniasis.
7/2010	Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis.

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Kevin D Read Research Topics

Disease

10	Visceral Leishmaniasis (Kala Azar) 01/2021 - 02/2012
10	African Trypanosomiasis (Nagana) 01/2018 - 04/2010
5	Infections 01/2019 - 11/2010
4	Neglected Diseases 01/2019 - 01/2011
3	Chagas Disease (American Trypanosomiasis) 08/2022 - 09/2015
3	Trypanosomiasis 01/2022 - 04/2010
3	Malaria 01/2019 - 01/2015
3	Epilepsy (Aura) 07/2011 - 07/2009
2	Parkinson Disease (Parkinson's Disease) 01/2019 - 01/2018
2	Psoriasis (Pustulosis Palmaris et Plantaris) 10/2018 - 01/2012
2	Tuberculosis (Tuberculoses) 10/2018 - 10/2013
2	Hypoxia (Hypoxemia) 01/2018 - 11/2016
2	Seizures (Absence Seizure) 08/2010 - 07/2009
1	Lymphoma (Lymphomas) 10/2020
1	B-Cell Lymphoma (Lymphoma, B Cell) 10/2020
1	Neoplasms (Cancer) 10/2020
1	Plague (Bubonic Plague) 11/2019
1	Alzheimer Disease (Alzheimer's Disease) 01/2019
1	Neuroinflammatory Diseases 01/2019
1	Cryptosporidiosis 01/2019
1	Huntington Disease (Huntington's Disease) 01/2019
1	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2019
1	Anemia 01/2018
1	Persistent Infection 10/2016
1	Multidrug-Resistant Tuberculosis (Drug-Resistant Tuberculosis) 01/2016
1	Drug-Related Side Effects and Adverse Reactions 09/2015
1	Pneumococcal Infections 07/2014
1	Skin Diseases (Skin Disease) 01/2012
1	Schizophrenia (Dementia Praecox) 07/2011
1	Bipolar Disorder (Manic Depressive Psychosis) 07/2011
1	Neurobehavioral Manifestations 07/2011
1	Cognitive Dysfunction 07/2011
1	Drug Resistant Epilepsy 08/2010
1	Central Nervous System Diseases (CNS Diseases) 03/2010

Drug/Important Bio-Agent (IBA)

21	Pharmaceutical PreparationsIBA 12/2020 - 03/2010
5	glycylpeptide N-tetradecanoyltransferaseIBA 10/2020 - 04/2010
5	EnzymesIBA 11/2019 - 10/2013
5	NifurtimoxIBA 01/2017 - 07/2010
4	Proteins (Proteins, Gene)FDA Link 10/2020 - 07/2004
3	benzonidazole (benznidazole)IBA 01/2017 - 09/2015
3	fexinidazoleIBA 10/2016 - 02/2012
3	Anticonvulsants (Antiepileptic Drugs)IBA 07/2011 - 07/2009
2	Cyclin-Dependent Kinases (cdk Proteins)IBA 01/2022 - 01/2018
2	pretomanidIBA 12/2020 - 10/2013
2	GSK3186899IBA 01/2019 - 01/2018
2	miltefosine (Impavido)IBA 01/2019 - 02/2012
2	ProdrugsIBA 01/2019 - 10/2013
2	Phosphotransferases (Kinase)IBA 01/2018 - 01/2018
2	OPC-67683IBA 11/2016 - 01/2016
2	Sodium Channel BlockersIBA 07/2011 - 08/2010
1	PiperazinesIBA 08/2022
1	Proteasome InhibitorsIBA 01/2021
1	NitroimidazolesIBA 12/2020
1	src-Family KinasesIBA 10/2020
1	PyrimidinesIBA 10/2020
1	KynurenineIBA 01/2019
1	Proteasome Endopeptidase Complex (Proteasome)IBA 01/2019
1	Lysine-tRNA LigaseIBA 01/2019
1	Kynurenine 3-Monooxygenase (Kynurenine 3 Monooxygenase)IBA 01/2019
1	ponesimodIBA 10/2018
1	LactamsIBA 10/2018
1	Anti-Bacterial Agents (Antibiotics)IBA 10/2018
1	AnthelminticsIBA 01/2018
1	Protein Kinases (Protein Kinase)IBA 01/2018
1	Von Hippel-Lindau Tumor Suppressor ProteinIBA 01/2018
1	Niclosamide FDA Link 01/2018
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 01/2018
1	prolyl T RNA synthetaseIBA 01/2017
1	Prolyl Hydroxylases (Prolyl Hydroxylase)IBA 11/2016
1	VH298IBA 11/2016
1	Chelating AgentsIBA 11/2016
1	IronIBA 11/2016
1	Nitro CompoundsIBA 11/2016
1	SulfonesIBA 10/2016
1	posaconazole FDA Link 09/2015
1	ER 30346 (ravuconazole)IBA 09/2015
1	AzolesIBA 09/2015
1	Messenger RNA (mRNA)IBA 01/2015
1	Guanosine Triphosphate (GTP)IBA 01/2015
1	Peptide Elongation Factor 2 (EF-2)IBA 01/2015
1	DDD107498IBA 01/2015
1	SulfonamidesIBA 12/2014
1	pyrazoleIBA 12/2014
1	C-Reactive ProteinIBA 07/2014
1	AntibodiesIBA 07/2014
1	NitroreductasesIBA 10/2013
1	Antitubercular AgentsIBA 10/2013
1	Antimony Sodium Gluconate (Sodium, Stibogluconate)IBA 02/2012
1	trypanothione synthetaseIBA 01/2012
1	Peroxisome Proliferator-Activated Receptors (PPAR)IBA 01/2012
1	Phencyclidine (Angel Dust)IBA 07/2011
1	Sodium Channels (Sodium Channel)IBA 07/2011
1	Lamotrigine (Lamictal)FDA LinkGeneric 07/2011
1	Opioid Analgesics (Opioids)IBA 11/2010
1	Phosphogluconate Dehydrogenase (Dehydrogenase, Phosphogluconate)IBA 08/2010
1	Eflornithine (Ornidyl)FDA Link 07/2010

Therapy/Procedure

5	Therapeutics 10/2020 - 03/2010
1	Oral Administration 01/2019
1	Duration of Therapy 10/2016
1	Drug Therapy (Chemotherapy) 02/2012